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Adult stem cell cancer

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730 17.07.2019
Cancer stem cells CSCs are cancer cells found within tumors or hematological cancers that possess characteristics associated with normal stem cells , specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic tumor-forming , perhaps in contrast to other non-tumorigenic cancer cells. Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease. Existing cancer treatments have mostly been developed based on animal models , where therapies able to promote tumor shrinkage were deemed effective.
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What are stem cells, and what do they do?

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Types of Stem Cell Transplants for Cancer Treatment | American Cancer Society

September 19, UCLA researchers have discovered genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues—which line all of the organs and cavities inside the body—and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how aggressive, treatment-resistant cancers develop and progress, and could eventually lead to new drugs for a range of advanced epithelial cancers such as lung, prostate and bladder cancers. Epithelial cancers account for 80 to 90 percent of all cancers diagnosed in the United States, according to the National Cancer Institute. Almost every type of epithelial cancer can develop into a highly aggressive form that metastasizes, or spreads rapidly to other organs in the body, and resists standard-of-care treatments such as radiation and chemotherapy. As part of a new and promising approach to cancer research, scientists are now seeking to uncover commonalities among these aggressive epithelial cancers in order to inform the development of "pan-cancer" therapies, those that can treat a range of cancers originating in different tissues. This new study identifies genetic features that are found across not only aggressive cancers from different epithelial tissues but also the human adult stem cells that renew and regenerate epithelial tissues throughout life.
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Researchers find adult stem cell characteristics in aggressive cancers from different tissues

Home Subjects adult stem cells Anna Azvolinsky Mar 27, The Scientist looks at one such Houston-based purveyor that has been treating patients abroad for years with mesenchymal stem cells. Shawna Williams Dec 11, Small trials using younger donors and elderly recipients hint that mesenchymal stem cell transfers might reduce frailty. Anna Azvolinsky Mar 23, A follow-up study confirms that random mutations acquired during normal stem cell division likely play a major role in cancer incidence. Anna Azvolinsky Jan 1, An analysis of 31 tissues finds that random mutations acquired during stem cell divisions correlate with lifetime cancer risk.
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Their findings could bring about a better understanding of how aggressive, treatment-resistant cancers develop and progress, and could eventually lead to new drugs for a range of advanced epithelial cancers such as lung, prostate and bladder cancers. Epithelial cancers account for 80 to 90 percent of all cancers diagnosed in the United States, according to the National Cancer Institute. Almost every type of epithelial cancer can develop into a highly aggressive form that metastasizes, or spreads rapidly to other organs in the body, and resists standard-of-care treatments such as radiation and chemotherapy. This new study identifies genetic features that are found across not only aggressive cancers from different epithelial tissues but also the human adult stem cells that renew and regenerate epithelial tissues throughout life. To do this, the collaborators utilized publicly available genetic data from healthy adult stem cells taken from patient intestines, mammary and prostate glands as well as cells from patients with different epithelial cancers including aggressive prostate and lung cancers.

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